Education & Research
Introduction of China National Clinical Research Center for Neurological Diseases
China National Clinical Research Center for Neurological Diseases (NCRC-ND) was formally founded in August 2013, under the leadership of Academician Zhao Jizong. Its founding marks a major move in the state’s effort to deepen medical system reforms and implement the 12th Five-Year Plan for Medical Science Development, and takes the lead in clinical medicine and transformation research on neurological diseases initiated by Ministry of Science and Technology and National Health and Family Planning Commission with the aim to improve medical science innovation system and clinical research capacity. As the only institution supporting the Center, Beijing Tiantan Hospital of Capital Medical University shoulders the arduous task of integrating the advantageous resources related to clinical research onneurological diseases nationwide to push forward clinical research and technical promotion of neuroscience in China.
Currently as the largest clinical medical research platform in China for neurological diseases, the Center is equipped with the world’s largest clinical data and sample banks meeting the international standard and the neurosurgery department ranking among the world’s top 3. It has 2 National Key Specialties of Ministry of Health, 2 National Key Disciplines of Ministry of Education, 1 State-Cultivated Key Discipline of Ministry of Education, and 1 National Center for Medical Quality Control of Neurology Departments. Since the “Eleventh Five-year Plan”, it has undertaken over 130 provincial or ministerial programs with the total funds amounting to RMB 264 million, has been granted 21 provincial or ministerial technology awards or above, and has published 530 SCI papers contributing to the impact factor 1221.087 points. In addition, the Center has laid a solid foundation owing to its extensive research in various fields including clinical evaluation for development of novel cerebrovascular drugs, national neuromodulation engineering lab, and translational medical research on brain tumors.
Positioning of the Center：
The National Clinical Research Center and the collaborative network are:
(1) an important component of the national medical technology innovation system;
(2) an important player in building biomedical capabilities;
(3) a major support for integrating the clinical medical research resources;
(4) the organizer and undertaker to advance clinical research and translational medicine for the relevant diseases; and
(5) the leading body in promoting clinical translation and grass-root level publicity of medical techniques.
Functions of the Center：
(1) Clinical medical research for prevention and control of neurological diseases to determine the priority in the prevention and control of neurological diseases in China;
(2) Technical evaluation and research for prevention and control of neurological disease to provide the state with the scientific evidences and decision-making consultation in formulating the regulations, policies, standards, technical guidelines and plans, etc., regarding prevention and control of neurological diseases.
(3) Constructing the nationalclinical study collaborative network for neurological diseases; organizing, monitoring and evaluating the implementation quality and effects of major research programs; establishing normalized clinical study management system and a result sharing mechanism for mutual improvement.
(4) Constructing an appropriate nationwide technical promotion network; demonstration and promotion of appropriate and effective techniques and measures for control of neurological disease to push forward neurological disease control nationwide.
(5) Relying on clinical research programs, integrating resource and scale-up to create the biosample bank for NCRC-ND, and exploring mechanisms for daily management of sample banks and for sample use and management.
(6) Training primary physicians on clinical research and disease control, normalized management of neurological diseases in communities, and providing data reference for effective control of neurological diseases and the risk factors in China.
(7) Expanding cooperation with corporates, domestic pharmaceutical corporates in particular, in a planned manner, and exploring the systems and mechanisms for converting research achievements into productivity, e.g., the transformation of major new drug innovations, medical device inventions and new technologies, so as to put valuable research achievements into clinical use and allow them to take effect as soon as possible.
(8) Boosting domestic and international academic exchanges, promoting cooperation with the WHO and other international organization in the prevention and control of neurological diseases, so as to enhance China’s international standing in this area.
The Center has generally established a professional public technical service platform for clinical research including study design department, project management team, academics and ethics committee, follow-up platform, data management and statistics center, quality control center andthird-party institutions including monitoring and management institutions, which is expected to further improve the quality and quantity of clinical research outputs; with regard to the collaborative research network, the Center has set up the first batch of 37 core institutions and over 200 collaborative institutions, which are expected to increase to over 700 through the promotional effort based on previous work, thus laying a foundation for large-scale clinical studies. Supported by Tiantan Hospital, the Center has also created biosample and patient banks on cerebrovascular diseases, brain tumors, neural degeneration, epilepsy, multiple necrosis, spinal cord tumors and other congenital or genetic neuropathies, which serve as a guarantee for subsequent intensive studies.
During theTwelfth Five-Year period, the Center will, depending on the rich clinical neurological research resources of Capital Medical University and Beijing Tiantan Hospital and integrating the medical institutions leading neuroscience development in China, scale up the collaborative research network, with the emphasis on explorative research of the cutting-edge techniques for cerebrovascular diseases and brain tumors, and research on promoting appropriate diagnosis and treatment techniques. Moreover, the Center will focus on promoting disciplinary development and nurturing talents, in pursuit of continuously improving China’s clinical research on neurological diseases.